Objective :
@EN Our purpose was to determine the clinical value of human papilloma virus deoxyribonucleic acid testing with the hybrid capture test, specfically to examine whether human papillomavirus testing could identify which women with Papanicolaou
smears
read
as atypical squamous cells of undetermined significance were most likely to have histologically confirmed cervical intraepithelial neoplasia.
@ES Study Design :
@EN Hybrid capture testing for high-risk human papillomavirus types(type 31, 33, 35, 45, 51, 52, 56), repeat Papanicolaou smears and colposcopically directed biopsies were performed concurrently on 55 women refered to chosun unversity hospital
with
a
previous Papanicolaou smear read as atypical squamous cells of undetermined significance.
@ES Results :
@EN Human papillomavirus deoxyribonucleic acid positivity was associated with a six fold increased likelihood of histologic confirmation of cervical intraepithelial neoplasia.
The sensitivity of hybrid capture for any cervical intraepithelial neoplasia was 92%(12/13) and specificity was 86%(36/42), whereas the corresponding values for the repeat Papanicilaou smear was 85%(11/13) and 38%(16/42), respectively.
@ES Conclusions :
@EN Testing for human papillomavirus deoxyribonucleic acid with hybrid capture appears to offer an effective means by which patients whose cervical Papanicolaou smears have been read as atypical squamous cells of undetermined significance could
be
triaged for colposcopy. In particular, high sensitivity and specificity for cervical intraepithelial neoplasia could be maintained.
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